Journal: Neurobiology of disease

Article Title: Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors

doi: 10.1016/j.nbd.2022.105634

Figure Lengend Snippet: Experimental setup and sequence for CognitionWall behavioral testing. Timeline of experiments (A) and depiction of the PhenoTyper layout (B) with the CognitionWall. Numbers of entries through left , middle and right entrance during the first 30 entries after protocol starts (C) . Total distance moved during the 4-day CognitionWall testing (D) . Total number of entries during the initial discrimination learning phase (E) and reversal learning phase (F) through any of the entrances ( left , middle and right ).

Article Snippet: Learning ability evaluation in 58 male C57BL/6J mice ( n = 24 in sham controls and n = 34 in LIB-exposed mice) was assessed at 3-months post LIB exposure with the PhenoTyper ® home-cages (Model 3000, Noldus Information Technology, The Netherlands) and CognitionWall TM system (Noldus Information Technology, The Netherlands) as previously described ( ; ; ; ).

Techniques: Sequencing

Journal: Neurobiology of disease

Article Title: Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors

doi: 10.1016/j.nbd.2022.105634

Figure Lengend Snippet: Dynamic patterns of learning deficits assessed by the HCM system. Frequency of left entries for food pellet rewards during the 96-h experimental period of the CognitionWall task (A) . Data acquisition was continuously during both the light and dark phases. Gray shadow represents the dark phase. The blue dotted lines show the duration of observed differences between sham controls and LIB-exposed mice. The average fractions of the correct entrances between specific entry numbers during the initial discrimination learning (B) and reversal learning phase (C) . * p < 0.05 by two-way ANOVA using Bonferroni post-tests.

Article Snippet: Learning ability evaluation in 58 male C57BL/6J mice ( n = 24 in sham controls and n = 34 in LIB-exposed mice) was assessed at 3-months post LIB exposure with the PhenoTyper ® home-cages (Model 3000, Noldus Information Technology, The Netherlands) and CognitionWall TM system (Noldus Information Technology, The Netherlands) as previously described ( ; ; ; ).

Techniques: